A process for the preparation of gemfibrozil

Details A process for the preparation of gemfibrozil A process for the preparation of gemfibrozil

C - Chemistry, Metallurgy

07

C

C07C 59/68 (2006.01) C07C 51/367 (2006.01)

Patent

CA 2163084

A process for the preparation of 2,2-dimethyl-5-(2,5-xylyloxy)-valeric acid, which process comprises the reaction of 2,5-dimethylphenol with a compound of formula (II), wherein R is an alkyl, aryl, arylalkyl group and X is a halogen atom, and the subsequent hydrolysis to compound (I), characterized in that the reaction of compound (II) with 2,5-dimethylphenol is carried out in the absence of solvents and in the presence of an ammonium or quaternary phosphonium salt.

Procédé de préparation d'acide 2,2-diméthyl-5-(2,5-xylyloxy)-valérique, consistant à faire réagir 2,5-diméthylphénol avec un composé de la formule (II), dans laquelle R représente un groupe alkyle, aryle, arylalkyle et X représente un atome d'hydrogène, et à hydrolyser ultérieurement ce composé pour former le composé (I). Ce procédé se caractérise en ce que la réaction du composé (II) avec 2,5-diméthylphénol a lieu en l'absence de solvants et en présence d'un sel d'ammonium ou de phosphonium quaternaire.

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