C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 267/00 (2006.01) A61K 31/395 (2006.01) C07C 43/315 (2006.01) C07C 59/58 (2006.01) C07C 69/007 (2006.01) C07C 235/28 (2006.01) C07D 273/02 (2006.01) C07F 7/18 (2006.01)
Patent
CA 2333551
The present invention relates to processes for the preparation of macrocyclic molecules containing anti-succinate residues which inhibit metalloproteinases such as aggrecanase, and the production of tumor necrosis factor (TNF). The anti-succinates are formed by an Ireland Claisen rearrangement of a silyl ketene acetal which proceeds with high stereoselectivity.
La présente invention se rapporte à des procédés pour préparer des molécules macrocycliques contenant des résidus anti-succinates qui inhibent des métalloprotéases telles que l'agrécanase et freinent la production du facteur de nécrose tumorale (TNF). Les anti-succinates sont formés par un réarrangement d'Ireland-Claisen de silyl cétène acétal qui passe par une stéréosélectivité élevée.
Campagna Silvio
Confalone Pasquale N.
Dorow Roberta L.
Jin Fuqiang
Wang Zhe
Bristol-Myers Squibb Pharma Company
Dimock Stratton Llp
Dupont Pharmaceuticals Company
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