A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 31/5415 (2006.01)
Patent
CA 2489708
The present invention relates to a process for the preparation of inclusion compounds of piroxicam with .beta.-cyclodextrin. More particularly, according to the process of the invention, the aqueous solution of two components is subjected, before drying, to a freezing process at very high rate. The resulting products have physico-chemical characteristics as well as technological and biopharmaceutical properties which are advantageous compared with those obtained according to the prior art processes. The resulting products are suitable for preparing pharmaceutical compositions for the oral administration.
La présente invention concerne un procédé pour préparer des composés d'inclusion de piroxicam et de .beta.-cyclodextrine. Selon ce procédé, la solution aqueuse de deux composants est soumise, avant séchage, à un processus de congélation à très grande vitesse. Les produits résultants présentent des caractéristiques physico-chimiques et des propriétés technologiques et biopharmaceutiques qui sont avantageuses par rapport à ceux obtenus au moyen des procédés de la technique antérieure. Les produits résultants sont adaptés à un usage dans la préparation de compositions pharmaceutiques à administration orale.
Capocchi Andrea
Chiesi Farmaceutici S.p.a.
Kirby Eades Gale Baker
LandOfFree
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