A process for the preparation of polypeptides from...

Details A process for the preparation of polypeptides from... A process for the preparation of polypeptides from...

C - Chemistry, Metallurgy

08

G

C08G 69/04 (2006.01) C07K 1/00 (2006.01) C07K 1/06 (2006.01) C07K 1/14 (2006.01) C07K 2/00 (2006.01) C07K 14/00 (2006.01) C08G 69/10 (2006.01) C08G 69/46 (2006.01) C08G 69/48 (2006.01) A61K 38/00 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2411786

A process for the preparation of a polypeptide designated in the present invention as 1, composed of the following amino acid units in the structure, namely: L- alanine, L-glutamic acid, L-lysine and L-tyrosine randomly arranged in the polypeptide 1, or pharmaceutically acceptable salts thereof, comprising the steps of: (a) polymerization of a mixture of the N-carboxyanhydrides of L-alanine, L- tyrosine, a protected L-glutamate and a protected L-lysine to obtain protected copolymer 6 or salt thereof; (see step 1) (b) deprotection of the protected copolymer 6 (or salt thereof) to produce polypeptide 1 or a pharmaceutically acceptable salt thereof in one single step; (see step 2) (c) separation and purification of the polypeptide 1 (or a pharmaceutically acceptable salt) to obtain a purified polypeptide 1. (see step 3)

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