A process for the preparation of quetiapine

Details A process for the preparation of quetiapine A process for the preparation of quetiapine

C - Chemistry, Metallurgy

07

D

C07D 281/16 (2006.01)

Patent

CA 2711395

The invention relates to a method for the preparation of 11-(4-[2-(2- hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo [b,f]-1,4-thiazepine and pharmaceutically acceptable salts thereof comprising the reaction of 1-[2-(hydroxyethoxy)-ethyl] piperazine with dibenzo[b,f][1,4]thiazepin-11-ylamine.

L'invention concerne un procédé de préparation de 11-(4-[2-(2-hydroxyéthoxy)éthyl]-1-pipérazinyl]dibenzo[b,f]-1,4-thiazépine et de ses sels pharmaceutiquement acceptables comprenant la réaction de transamination de la 1-[2-(hydroxyéthoxy)-éthyl]pipérazine avec de la dibenzo[b,f][1,4]thiazépin-11-ylamine.

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