A process for the preparation of ribonucleotide reductase...

Details A process for the preparation of ribonucleotide reductase... A process for the preparation of ribonucleotide reductase...

C - Chemistry, Metallurgy

07

H

C07H 19/173 (2006.01) C07D 239/47 (2006.01) C07F 7/10 (2006.01) C07F 7/22 (2006.01) C07H 19/06 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2133961

The present invention is directed toward a novel process of 2'-exocyclic vinylfluoride derivatives of cytidine analogues (I) for use as ribonucleoside reductase inhibitors, wherein V is oxy or methylene and Y is hydrogen, C1-C4 alkyl or C1-C4 alkoxy.

La présente invention concerne un nouveau procédé de fabrication de dérivés d'analogues de la cytidine (I) portant un fluorure de vinyle exocyclique en 2' pour utilisation comme inhibiteurs de la ribonucléoside-réductase, où V est un groupement oxy ou méthylène et Y est un atome d'hydrogène, un alkyle en C1-C4 ou un alcoxy en C1-C4.

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