A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/72 (2006.01) A61K 9/12 (2006.01) A61K 31/573 (2006.01) A61L 2/08 (2006.01)
Patent
CA 2614633
The invention is directed to a process for the preparation of suspensions of drug particles for inhalation delivery, said process providing particles of optimised particle size and distribution homogeneously dispersed in the carrier. The process, which is also suitable for the preparation of sterile suspensions, includes the step of homogenising and micronising the formulation in a turboemulsifier provided with a high--potency turbine, optionally followed by a treatment in a high--pressure homogeniser.
La présente invention est orientée vers un procédé de préparation de suspensions de particules de médicament pour administration par inhalation; ce procédé donnant des particules de taille optimisée et une distribution dispersée de façon homogène dans le porteur. Ce procédé, qui convient également pour la préparation de suspensions stériles, comprend l'opération d'homogénéisation et de micronisation de la formulation dans un turboémulsifieur équipé d'une turbine à haute activité, suivie facultativement d'un traitement dans un homogénéiseur haute pression.
Bernini Eva
Brambilla Gaetano
Chiesi Paolo
Garzia Raffaella
Malvolti Chiara
Chiesi Farmaceutici S.p.a.
Kirby Eades Gale Baker
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