A process for the preparation of the apoptosis promoter abt-263

Details A process for the preparation of the apoptosis promoter abt-263 A process for the preparation of the apoptosis promoter abt-263

C - Chemistry, Metallurgy

07

D

C07D 295/155 (2006.01)

Patent

CA 2727932

A process for the preparation of the apoptosis promoter N-(4-(4-((2-(4- chlorophenyl)-5,5- dimethyl- 1-cyclohex- 1-en- 1-yl)methyl)piperazin- 1-yl)benzoyl)-4-((( 1 R)-3-(morpholin-4-yl)- 1- ((phenylsulfanyl) methyl)propyl)amino)-3-(trifluo- romethyl)sulfonyl)benzenesulfonamide (A B T-263). Formula (I).

L'invention concerne un procédé pour préparer le promoteur d'apoptose N-(4-(4-((2-(4-chlorophenyl)-5,5- dimethyl- 1 -cyclohex- 1 -en- 1 -yl)methyl)piperazin- 1 -yl)benzoyl)-4-((( 1 R)-3-(morpholin-4-yl)- 1-((phenylsulfanyl) methyl)propyl)amino)-3-(trifluoromethyl)sulfonyl)benzenesulfonamide (ABT-263) représenté par la formule (I).

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