C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01)
Patent
CA 2631459
A process for the preparation of (S)-omeprazole from racemic omeprazole via the formation of an inclusion complex with (S)-1,1,2-triphenyl-1,2-ethanediol. (S)-Omeprazole is recovered in a substantially optically pure form either in neutral form or as a pharmaceutically acceptable salt or as its solvates including hydrates. The (S)-omeprazole 2[(S)-1,1,2-triphenyl-1,2-ethanediol] inclusion complex is new. This resolution process proceeds with high yields and high optical purity.
La présente invention concerne un procédé pour la préparation de (S)-oméprazole à partir d'oméprazole racémique par la formation d'un complexe d'inclusion avec le (S)-1,1,2-triphényl-1,2-éthanediol. Le (S)-oméprazole est récupéré sous une forme sensiblement optiquement pure, sous une forme neutre ou sous forme de sel pharmaceutiquement acceptable ou sous forme de ses solvates comprenant des hydrates. Le complexe d'inclusion (S)-oméprazole-2[(S)-1,1,2-triphényl-1,2-éthanediol] est nouveau. Ce procédé de résolution produit des rendements élevés et une pureté optique élevée.
Comely Alexander
Coto Antonio Domingo
Rafecas Jane Llorenc
Verdaguer Espaulella Xavier
Robic
Union Quimico Farmaceutica S.a.
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