C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 213/08 (2006.01) A61K 31/135 (2006.01) A61P 25/24 (2006.01) C07C 217/74 (2006.01)
Patent
CA 2380854
Process for producing venlafaxine and/or physiologically acceptable addition salts thereof, consisting in reacting a compound having the general formula (II) wherein R is a C1-C10 alkyl group, aryl group, aralkyl group or cycloalkyl group having from 3 to 6 carbon atoms, with an organomagnesian compound having the general formula (III) wherein X is a halogen atom and, if desired, a salt of venlafaxine can be obtained by reaction with a physiologically acceptable acid.
L'invention concerne un procédé de production de venlafaxine et/ou de ses sels d'addition physiologiquement acceptables qui consiste à faire réagir un composé représenté par la formule générale (II) dans laquelle R représente un groupe alkyle C¿1?-C¿10?, aryle, aralkyle ou cycloalkyle ayant de 3 à 6 atomes de carbone, avec un composé organomagnésien représenté par la formule générale (III) dans laquelle X représente un atome d'halogène et, le cas échéant, on forme un sel de la venlafaxine obtenue au moyen de sa réaction avec un acide physiologiquement acceptable.
Arnalot I. Aguilar Carmen
Bosch I. Llado Jordi
Camps Garcia Pelayo
Onrubia Miguel Maria Del Carmen
Soldevila Madrid Nuria
Medichem S.a.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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