A process for the purification of antibodies

Details A process for the purification of antibodies A process for the purification of antibodies

B - Operations, Transporting

01

D

B01D 15/08 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2552639

The present invention relates to a process for the purification of antibodies from one or more impurities in a liquid, which process comprises contacting said liquid with a first chromatography resin comprised of a support to which multi-modal ligands have been immobilised to adsorb the antibodies to the resin, wherein each multi-modal ligand comprises at least one cation- exchanging group and at least one aromatic or heteroaromatic ring system; adding an eluent to release the antibodies from the resin; and contacting the eluate so obtained with a second chromatography resin. In one embodiment, the ring-forming atoms of the aromatic or heteroaromatic entity are selected from the group con-sisting of C, S and O, and the cation exchanging group is a weak cation exchanger.

L'invention porte sur un procédé de purification d'anticorps à partir d'une ou de plusieurs impuretés présentes dans un liquide consistant: à mettre ledit liquide en contact avec une première résine de chromatographie servant de support dans lequel ont été immobilisés des ligands multimodes qui absorbent les anticorps à l'intérieur la résine, chacun desdits ligands multimodes comportant au moins un groupe échangeur de cations et au moins un système de cycles aromatiques ou hétéroaromatique. Dans une exécution, les atomes formant les cycles de l'entité aromatique ou hétéroaromatique sont sélectionnés parmi C, S et O, tandis que le groupe échangeur de cations est un échangeur de cations faibles.

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