A process for the purification of gabapentin

Details A process for the purification of gabapentin A process for the purification of gabapentin

C - Chemistry, Metallurgy

07

C

C07C 227/40 (2006.01) C07C 229/28 (2006.01)

Patent

CA 2590232

The present invention relates to a process for the purification of gabapentin. The process relates to the addition of hydrochloric acid to an aqueous solution or suspension of gabapentin, before, during or after the concentration step of that solution, and the subsequent slurry of the gabapentin by the addition of an alcoholic solvent. The so obtained gabapentin has an high purity degree and, in particular, is characterized by a low content of lactam.

La présente invention porte sur un procédé de purification de la gabapentine. Ce procédé consiste à ajouter un acide chlorhydrique à une solution ou suspension aqueuse de gabapentine, avant, pendant ou après l'étape de concentration de cette solution, et la boue obtenue de la gabapentine par addition d'un solvant à base d'alcool. La gabapentine ainsi obtenue est d'une haute pureté et est, notamment, caractérisée par une faible teneur en lactame.

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