A process for the purification of ropinirole hydrochloride

Details A process for the purification of ropinirole hydrochloride A process for the purification of ropinirole hydrochloride

C - Chemistry, Metallurgy

07

D

C07D 209/34 (2006.01)

Patent

CA 2645599

The present invention provides an improved process for the purification of Ropinirole hydrochloride of formula (Ia) comprising steps of: (i) dissolving Ropinirole hydrochloride in water; (ii) treating the solution obtained in step (i) with sodium dithionate and charcoal; (iii) treating the filtrate obtained in step (ii) with water immiscible solvent and base and isolating the free base; (iv) treating the free base obtained in step (iii) with ethanolic HCl to give Ropinirole hydrochloride.

La présente invention concerne un procédé amélioré de purification du chlorhydrate de Ropinirole représenté par la formule (Ia). Ce procédé consiste: (i) à dissoudre dans l'eau le chlorhydrate de Ropinirole; (ii) à traiter au dithionate de sodium et au charbon de bois la solution résultant de (i); (iii) à prendre le filtrat résultant de (ii) et à le traiter avec un solvant non miscible avec l'eau et une base, puis à isoler la base libre; et enfin (iv) à prendre la base libre résultant de (iii) et à la traiter avec un chlorhydrate éthanolique pour obtenir le chlorhydrate de Ropinirole.

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