A process for the purification of ropinirole hydrochloride

Details A process for the purification of ropinirole hydrochloride A process for the purification of ropinirole hydrochloride

C - Chemistry, Metallurgy

07

D

C07D 209/34 (2006.01)

Patent

CA 2647790

The present invention provides an improved process for the purification of Ropinirole hydrochloride of formula (Ia) comprising steps of: (i) treating Ropinirole hydrochloride with sodium dithionate and charcoal in suitable alcoholic solvent; (ii) triturating Ropinirole hydrochloride obtained in step (i) with ethanol; (iii) reacting the triturated solid with base in water immiscible solvent and isolating the free base; (iv) treating the free base obtained in step (iii) with ethanolic HCl to give Ropinirole hydrochloride.

La présente invention concerne un procédé amélioré de purification du chlorhydrate de Ropinirole représenté par la formule (Ia). Ce procédé consiste: (i) à traiter le chlorhydrate de Ropinirole avec du dithionate de sodium et du charbon de bois dans un solvant alcoolique approprié; (ii) à triturer avec de l'éthanol le chlorhydrate de Ropinirole résultant de (i); (iii) à faire réagir le solide trituré avec une base dans un solvant non miscible avec l'eau et à isoler la base libre; et (iv) à prendre la base libre résultant de (iii) et à la traiter avec un chlorhydrate éthanolique pour obtenir le chlorhydrate de Ropinirole.

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