A process for the simultaneous production of artemisinin and...

Details A process for the simultaneous production of artemisinin and... A process for the simultaneous production of artemisinin and...

C - Chemistry, Metallurgy

07

D

C07D 493/18 (2006.01) C07C 51/48 (2006.01) C07C 57/26 (2006.01) C11B 5/00 (2006.01) C11B 9/02 (2006.01) C11B 13/00 (2006.01)

Patent

CA 2218444

This invention relates to a novel process for the dual production of essential oil and artemisinin from the plant Artemisia annua, said process comprising extracting the plant with hexane, partitioning the hexane extract between hexane and acetonitrile, hydrodistillation of hexane residue and Marc to yield essential oil, further fractionation of acetonitrile solvent between hexane- benzene mixture to remove artemisinic acid, chromatographing of the acetonitrile phase to produce substancially pure artemisinin, the artemisinic acid is reduced to obtain dihydro artemisinic acid which is then oxidised in a single step to foam artemisinin.

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