C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/04 (2006.01) C07D 311/58 (2006.01) C07D 491/04 (2006.01)
Patent
CA 2462156
A process for the stereoselective synthesis of 2-hydroxymethyl-chromans of formula (II) is provided where R, R1, R2 and R3 are as defined herein. The compound of formula (II) is prepared using an optically active benzene compound of formula (I) where R0 is as defined herein. The 2-hydroxymethyl- chroman compounds of formula (II) are useful as intermediates for preparing a variety of medicinal agents.
L'invention concerne un procédé destiné à la synthèse stéréosélective de 2-hydroxyméthyl-chromanes de formule (II), dans laquelle R, R?1¿ et R?2¿ sont tels que définis dans la description. Le composé de formule (II) est préparé au moyen d'un composé benzène optiquement actif de formule (I), dans laquelle R?0¿ est tel que défini dans la description. Les composés 2-hydroxyméthyl-chromanes de formule (II) sont utiles comme produits intermédiaires pour la préparation d'une pluralité d'agents thérapeutiques.
Gross Jonathan Laird
Stack Gary Paul
Torys Llp
Wyeth
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