A process for the synthesis of atorvastatin form v and...

Details A process for the synthesis of atorvastatin form v and... A process for the synthesis of atorvastatin form v and...

C - Chemistry, Metallurgy

07

F

C07F 5/02 (2006.01) A61K 31/40 (2006.01) A61P 3/06 (2006.01) C07D 207/34 (2006.01)

Patent

CA 2436122

The present invention discusses a novel process for the synthesis of [R- (R*,R*)]-2(4-fluorophenyl)-B,D-dihydroxy-5-(1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium, atorvastatin form V. The compound so prepared is useful as inhibitors of the enzyme HMG-CoA reductase and are thus used as hypolipidemic and hypocholesterolemic agents.

La présente invention concerne un nouveau procédé de synthèse d'un sel d'hémi-calcium d'acide [R-(R*,R*)]-2(4-fluorophényl)-B,D-dihydroxy-5-(1-méthyléthyl)-3-phényl-4-[(phénylamino)carbonyl]-1H-pyrrole-1-heptanoïque, soit la forme V de l'atorvastatine. Le composé ainsi préparé est utile en tant qu'inhibiteur de la HMG-CoA réductase et il est par conséquent utilisé en tant qu'agent hypolipidémique et hypocholestérolémique.

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