A process for the synthesis of beta-lactam derivatives

Details A process for the synthesis of beta-lactam derivatives A process for the synthesis of beta-lactam derivatives

C - Chemistry, Metallurgy

07

D

C07D 501/04 (2006.01) C07D 501/00 (2006.01)

Patent

CA 2380183

A process for the preparation of Cefuroxime acid or of a corresponding pharmaceutically acceptable salt or ester, by reaction of a 3- hydroxymethylceph-3-em precursor thereof with activated isocyanates in carbonic acid esters.

L'invention concerne un procédé permettant la préparation d'acide de Cefuroxime ou d'un sel ou d'un ester pharmaceutiquement acceptables de ce composé. Ce procédé consiste à faire réagir un précurseur 3-hydroxyméthylceph-3-em de ce composé avec des isocyanates activés, dans des esters d'acide carbonique.

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