C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 317/60 (2006.01) C07C 49/84 (2006.01) C07C 305/26 (2006.01) C07C 309/65 (2006.01) C07D 213/50 (2006.01) C07D 317/50 (2006.01) C07D 405/04 (2006.01) C07F 5/02 (2006.01)
Patent
CA 2236926
Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentanopyridine derivatives. The most preferred compounds prepared by this invention are (+)(1S, 2R, 3S)-3-[2-(2-hydroxyeth-1- yloxy)-4-methoxyphenyl]-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2- carboxylic acid and pharmaceutically acceptable salts thereof and (+)(1S, 2R, 3S)-3-(2-carboxymethoxy-4-methoxyphenyl)-1-(3,4-methylenedioxyphenyl)-5-(prop- 1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof. Also invented are novel intermediates useful in preparing these compounds.
L'invention concerne un procédé amélioré pour préparer des dérivés du type cyclopentane fusionné avec un noyau aromatique. Les composés préférés préparés selon cette invention sont des dérivés indane carboxylate et des dérivés cyclopentano pyridine. Les composés particulièrement préférés de cette invention sont l'acide (+)(1S, 2R, 3S)-3-[2-(2-hydroxyéth-1-yloxy)-4-méthoxyphényl]-1-(3,4-méthylènedioxyphényl)-5-(prop-1-yloxy)indane-2-carboxylique et ses sels acceptables sur le plan pharmaceutique, ainsi que l'acide (+)(1S,2R,3S)-3-(2-carboxyméthoxy-4-méthoxyphényl)-1-(3,4-méthylènedioxyphényl)-5-(prop-1-yloxy)indane-2-carboxylique et ses sels acceptables sur le plan pharmaceutique. L'invention concerne aussi de nouveaux intermédiaires utiles pour préparer ces composés.
Clark William Morrow
Lantos Ivan
Mills Robert John
Pridgen Lendon Norwood
Tickner Ann Marie
Gowling Lafleur Henderson Llp
Smithkline Beecham Corporation
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