A process to prepare a pharmaceutically acceptable salt of...

Details A process to prepare a pharmaceutically acceptable salt of... A process to prepare a pharmaceutically acceptable salt of...

C - Chemistry, Metallurgy

07

K

C07K 5/062 (2006.01) A61K 38/05 (2006.01) A61P 9/00 (2006.01) C07K 5/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2506587

A pharmaceutically acceptable salt of perindopril of formula (I) is made from a protected precursor compound of formula (II) wherein R represents a carboxyl protecting group, which process comprises subjecting a compound of formula (II) to deprotection of the carboxylic group COOR attached to the heterocyclic ring so as to yield the corresponding free acid, which deprotection is carried out in the presence of a base which forms a pharmaceutically acceptable salt with said free acid formed by said deprotection.

L'invention concerne un sel pharmaceutiquement acceptable de périndopril de formule (I) obtenu à partir d'un composé précurseur protégé de formule (II), dans laquelle R représente un groupe de protection carboxyle. Le procédé de l'invention comprend l'étape suivante : soumettre un composé de formule (II) à la déprotection du groupe carboxylique COOR fixé sur le noyau hétérocyclique, de façon à rendre l'acide libre correspondant, la déprotection étant effectuée en présence d'une base qui forme un sel pharmaceutiquement acceptable avec ledit acide libre formé par ladite déprotection.

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