C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2254889
The present invention provides the base sequence defined as Sequence No. 1, DNA comprising a part of the sequence, or DNA containing the sequence, and relates to a promoter gene of the porcine complement inhibitor. In generating transgenic pigs transformed with human complement inhibitor and/or such thrombosis-inhibiting factors as thrombomudulin (collectively termed the complement inhibitor), DNA of the invention can effectively be used to express the complement inhibitor by integrating the gene into the upstream part of the human complement-inhibitor gene. Since hyperacute rejection, which occurs on transplanting a porcine organ or tissue to man, can be prevented, xenotransplantaion of the porcine organs and tissues to man will become possible. Therefore, the problem of the lack of donors for transplantation can be solved.
L'invention porte sur des ADN consistant en la séquence de base et représentée par la SEQ ID N DEG : 1 ou ses parties, ou sur des ADN comportant ladite séquence de base et servant de promoteurs d'inhibiteurs complémentaires porcins. Dans la création de porcs transgéniques présentant des inhibiteurs complémentaires humains et/ou des facteurs inhibant la formation des thrombus tels que la thrombomoduline (dits ici inhibiteurs complémentaires), les inhibiteurs complémentaires humains peuvent être efficacement exprimés par intégration des ADN susmentionnés à la production d'inhibiteurs complémentaires humains. En conséquence, ces ADN permettent d'empêcher les rejets suraigus survenant lors de la transplantation de tissus ou d'organes porcins dans l'homme. On arrive ainsi à solutionner le problème du manque de donneurs d'organes pour les transplantations.
Fujimura Tatsuya
Murakami Hiroshi
Shigehisa Tamotsu
Toyomura Koji
Nippon Meat Packers Inc.
Riches Mckenzie & Herbert Llp
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