A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 47/48 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2214799
The present invention relates to a pharmaceutical composition for the prevention or treatment of diseases or conditions involving stress injury to cells, the composition comprising (a) a lipid-containing substance having a lipid portion which is structurally identical with or analogous to a ceramide, conjugated to (b) a protein capable of binding said lipid-containing substance in such a way that, when the conjugate is contacted with living cells, the lipid-containing substance activates a ceramide-activated protein phosphatase resulting in down-regulation of cellular metabolism, and (c) a pharmaceutically acceptable diluent or carrier.
La présente invention concerne une composition pharmaceutique pour la prévention ou le traitement de maladies ou de troubles liés à des lésions causées à des cellules par diverses agressions. Cette composition contient (a) une substance contenant un lipide ayant une portion lipidique qui est identique du point de vue structure ou analogue à celle d'un céramide, conjuguée à (b) une protéine capable de fixer cette substance contenant un lipide de manière à ce que, quand le conjugué est en contact avec des cellules vivantes, ladite substance contenant un lipide active une protéine phosphatase activée par un céramide, ce qui provoque une diminution du métabolisme cellulaire et (c) un diluant ou vecteur acceptable sur le plan pharmaceutique.
Flodgaard Hans
Rasmussen Poul Baad
Leukotech A/s
Mccarthy Tetrault Llp
Novo Nordisk A/s
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