A pyridine-1-oxide derivative, and process for its...

Details A pyridine-1-oxide derivative, and process for its... A pyridine-1-oxide derivative, and process for its...

C - Chemistry, Metallurgy

07

D

C07D 213/89 (2006.01)

Patent

CA 2406266

The invention relates to N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1- oxide-3-carboxamidine and its optically active enantiomers. (R)-(-)-N-[2-hydroxy-3-(1-piperidinyl)- propoxy]-pyridine-1-oxide-3-carboxamidine and (S)-(+)-N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3- carboxamidine. Furthermore, the invention relates to the preparation of N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3- carboxyimidoyl chloride, which may be used as an active ingredient of medicaments, and the preparation of the optically active enantiomers of this compound using the compounds of the invention as intermediate substances.

La présente invention concerne N-[2-hydroxy-3-(1-piperidinyle)-propoxy]-pyridine-1-oxyde-3-carboxamidine et ses énantiomères optiquement actifs, (R)-(-)-N-[2-hydroxy-3-(1-piperdinyle)-propoxy]-pyridine-1-oxyde-3-carboxamidine et (S)-(+)-N-[2-hydroxy-3-(1-piperidinyle)-propoxy]-pyridine-1-oxyde-3-carboxamidine. Cette invention concerne aussi la préparation de N-[2-hydroxy-3-(1-piperidinyle)-propoxy]-pyridine-1-oxyde-3-carboxyimidoyl chlorure, qui peut être utilisé comme principe actif de médicaments, et la préparation des énantiomères optiquement actifs de ce composé par utilisation des composés de l'inventions sous forme de substances intermédiaires.

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