A radioisotope-chitosan complex for treatment of prostate...

A - Human Necessities – 61 – K

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A61K 51/00 (2006.01)

Patent

CA 2537493

Disclosed is a composition for treating prostate cancer. The composition for treating prostate cancer comprises as an effective ingredient a radioisotope- chitosan complex that includes a therapeutic radioisotope emitting beta radiation and chitosan. Also, the present invention discloses a kit for preparing the composition. When directly administered to a prostate cancer tissue, the radioisotope-chitosan complex is deposited in the applied target site while not leaking from the applied target site, and strongly inhibits the growth of prostate cancer cells while minimizing the side effects of conventional therapies, including urinary incontinence, urethral stricture and rectal bleeding. In addition, the radioisotope-chitosan complex may be used as an effective therapeutic agent for hormone-independent prostate cancer that is resistant to hormone therapy.

L'invention concerne une composition destinée au traitement du cancer de la prostate. Cette composition destinée au traitement du cancer de la prostate comprend comme principe actif un complexe de chitosane radio-isotope qui contient un radio-isotope thérapeutique émettant un rayonnement bêta et du chitosane. Cette invention concerne également un nécessaire destiné à préparer cette composition. Lorsque la composition de l'invention est directement administrée à des tissus atteints du cancer de la prostate, le complexe de chitosane radio-isotope est déposé dans le site cible affecté sans fuite du site cible affecté, et inhibe fortement la croissance des cellules du cancer de la prostate, tout en minimisant les effets secondaires des traitements classiques, notamment l'incontinence urinaire, le rétrécissement de l'urètre et le saignement rectal. En outre, le complexe de chitosane radio-isotope peut être utilisé en tant qu'agent thérapeutique efficace contre le cancer de la prostate, indépendant des hormones, qui résiste aux thérapies hormonales.

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