A rapid acting freeze dired oral pharmaceutical composition...

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/00 (2006.01) A61K 9/19 (2006.01) A61K 9/20 (2006.01) A61K 31/138 (2006.01) A61K 31/4045 (2006.01) A61K 31/4196 (2006.01) A61K 31/42 (2006.01) A61K 31/48 (2006.01) A61P 25/06 (2006.01)

Patent

CA 2392810

The present invention relates to a novel freeze - dried pharmaceutical composition useful for the treatment of migraine and associated symptoms at a reduced total dose of active substance than required for oral administration in the form of a tablet comtaining a porous matrix net work of a water soluble or water dispersible carrier material, a pharmaceutically active substance(s); organoleptic additives such as sweetening agents, flavouring agents, coloring agents; pharmaceutically acceptable preservatives; solublising agents; surfaceactive agents and/or buffereing agents. The pharmaceutical composition optionally may contain other additives such as permeation enhancers, chelating salts and stabilising agents. The present invention also relates to a process for preparation of the above said composition and its use.

La présente invention concerne une nouvelle composition pharmaceutique lyophilisée utile pour traiter la migraine et les symptômes associés avec une dose totale de substrat actif réduite par rapport à la dose requise pour l'administration par voie orale sous forme d'un comprimé contenant un réseau de matrice poreuse constitué d'un matériau de support soluble dans l'eau ou dispersable dans l'eau, au moins un substrat pharmaceutiquement actif ; des additifs organoleptiques tels que des agents édulcorants, des aromatisants, des colorants; des conservateurs pharmaceutiquement acceptables; des agents de solubilisation; des agents tensioactifs et/ou des agents de tamponnage. La composition pharmaceutique peut également contenir d'autres additifs tels que des activateurs de perméation, des sels chélateurs et des agents de stabilisation. Cette invention concerne également un procédé de préparation de la composition selon l'invention et un procédé d'utilisation de cette dernière.

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