A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/14 (2006.01) A61K 31/4468 (2006.01) A61P 25/04 (2006.01) A61K 47/34 (2006.01) A61K 47/38 (2006.01)
Patent
CA 2512559
A pharmaceutical composition for the treatment of acute disorders is described. The composition comprises an essentially water-free, ordered mixture of at least one pharmaceutically active agent in the form of microparticles which are adhered to the surfaces of carrier particles which are substantially larger than the particles of the active agent or agents, and are essentially insoluble or sparingly soluble in water, in combination with a bioadhesion and/or mucoadhesion promoting agent adhered to the surfaces of said carrier particles. The composition is primarily intended for sublingual or intranasal administration. The invention also relates to a method for preparing the composition and to the use of the composition for the treatment of acute disorders.
L'invention concerne une composition pharmaceutique pour le traitement de troubles aigus. Cette composition comprend un mélange ordonné, pratiquement exempt d'eau, d'au moins un principe pharmaceutiquement actif se présentant sous la forme de microparticules qui adhèrent aux surfaces de particules d'excipient, dont la taille est sensiblement supérieure à celle des particules du ou des principes actifs et qui sont pratiquement insolubles ou peu solubles dans l'eau, en combinaison avec un agent favorisant la bio-adhésion et/ou la muco-adhésion et adhérant aux surfaces desdites particules d'excipient. Cette composition est principalement destinée à être administrée par voie sublinguale ou intranasale. L'invention concerne également un procédé pour préparer ladite composition et l'utilisation de cette dernière pour le traitement de troubles aigus.
Bredenberg Susanne
Nystrom Christer
Borden Ladner Gervais Llp
Orexo Ab
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