C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 35/12 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) C12N 15/62 (2006.01) C12N 15/863 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) C40B 30/00 (2006.01) G01N 33/68 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2678259
The present invention is a recombinant vector encoding and expressing at least three or more costimulatory molecules. The recombinant vector may additionally contain a gene encoding one or more target antigens or immunological epitope thereof. The synergistic effect of these costimulatory molecules on the enhanced activation of T cells is demonstrated. The degree of T-cell activation using recombinant vectors containing genes encoding three costimulatory molecules was far greater than the sum of recombinant vector constructs containing one costimulatory molecule and greater than the use of two costimulatory molecules. Results employing the triple costimulatory vectors were most dramatic under conditions of either low levels of first signal or low stimulator to T-cell ratios. This phenomenon was observed with both isolated CD4+ and CD8+ T cells. The recombinant vectors of the present invention are useful as immunogenes and vaccines against cancer and pathogenic micro-organisms, and in providing host cells, including dendritic cells and splenocytes with enhanced antigen-presenting functions.
Hodge James
Panicali Dennis
Schlom Jeffrey
Department Of Health & Human Services The Government Of The United States Of America As Represented By
Department Of Health And Human Services The Government Of The United States Of America As Represented By
Sim & Mcburney
LandOfFree
A recombinant vector expressing multiple costimulatory... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with A recombinant vector expressing multiple costimulatory..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and A recombinant vector expressing multiple costimulatory... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1939660