A reference compound for use in the analysis of levosimendan...

C - Chemistry – Metallurgy – 07 – D

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C07D 307/33 (2006.01) G01N 30/86 (2006.01) G01N 30/89 (2006.01)

Patent

CA 2334864

The present invention relates to a pyridazinyl derivative (I) and its use as a reference compound in the determination of potentially genotoxic impurities in levosimendan samples. The invention also relates to an analytic method for the determination of potentially genotoxic impurities in levosimendan samples wherein (I) is used as a reference compound. Levosimendan is a medicament useful in the treatment of heart failure.

L'invention concerne un dérivé de pyridazinyle (I) et son utilisation comme composé de référence pour la détermination des impuretés potentiellement génotoxiques dans des échantillons de lévosimendan. L'invention concerne en outre un procédé analytique permettant de déterminer lesdites impuretés dans les échantillons en question, sachant que l'on utilise pour cela le produit de formule (I) comme composé de référence. Le lévosimendan est un médicament utile pour le traitement des défaillances cardiaques.

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