A regioselective palladium catalyzed synthesis of...

C - Chemistry – Metallurgy – 07 – D

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C07D 235/10 (2006.01) C07D 235/02 (2006.01) C07D 235/08 (2006.01) C07D 235/12 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2657717

The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein RO; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct palladium catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula (I) starting from 2-halo-nitroarenes and .LAMBDA./-substituted amides useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricitdes and arthropodicides.

La présente invention concerne un procédé de synthèse régiosélective de composés représentés par la formule (I) dans laquelle RO; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q et J sont tels que spécifiés dans les revendications. Cette invention concerne un procédé régiosélectif catalysé par le palladium destiné à une grande diversité de benzimidazoles ou d'azabenzimidazoles multifonctionnelsN-substitués représentés par la formule (I) à partir de 2-halo-nitroarènes et d'amides .LAMBDA./-substituées utiles pour produire des produits pharmaceutiques, des agents de diagnostic, des cristaux liquides, des polymères, des herbicides, des fongicides, des nématicides, des antiparasitaires, des insecticides, des acaricides et des arthropodicides.

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