A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/28 (2006.01)
Patent
CA 2526464
The invention relates to a simple and improved osmotic device for the controlled release of an active agent from the core into the use environment. According to the invention, the active agent is first released through a preformed passage and, subsequently, through a second passage which is formed in situ. Optionally, the size of one or both of the passages increases during the use of the osmotic device. Moreover, the preformed passage and/or the second passage increases the release speed of the active agent and enables the release of larger particles containing the active agent and/or the release of active agents which are essentially insoluble in the use environment. Owing to the in situ formation of the second opening, the device can release a greater percentage of active agent than that which would be released without said second opening.
La présente invention concerne un dispositif osmotique simple et perfectionné permettant la libération contrôlée d'un agent actif contenu dans le noyau dans l'atmosphère utilisée, d'abord à travers le passage préformé, puis à travers le second passage formé in situ. La dimension d'un des deux ou des deux passages augmente éventuellement au cours de l'utilisation du dispositif osmotique. Le passage préformé et/ou le second passage permettent d'augmenter la vitesse de libération de l'agent actif, permettant la libération de grandes particules contenant l'agent actif, et/ou la libération d'agents actifs sensiblement insolubles dans l'atmosphère utilisée. Grâce à la formation in situ de la seconde ouverture, le dispositif peut libérer un pourcentage d'agent actif supérieur à celui libéré en l'absence de la seconde ouverture.
Faour Joaquina
Vergez Juan A.
Goudreau Gage Dubuc
Osmotica Costa Rica Sociedad Anonima
Osmotica Kereskedelmi Es Szolgaltato Kft
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