C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/58 (2006.01) A61K 31/35 (2006.01)
Patent
CA 2291732
A new salt (R)-3-N,N-dicyclobutylamino-8-fluoro-3,4-dihydro-2H-1-benzopyran-5- carboxamide hydrogen tartrate, particularly the (2R,3R)-tartrate thereof, most particularly the (R)-3-N,N-dicyclobutylamino-8-fluoro-3,4-dihydro-2H-1- benzopyran-5-carboxamide hydrogen (2R,3R)-tartrate monohydrate, processes for the manufacture of said tartrate salt, the use of the salt in medicine, the use of the tartrate salt in the manufacture of pharmaceutical formulations, and a method for the treatment of CNS disorders by administration of the tartrate salt to a host in need of such treatment.
L'invention concerne un nouveau hydrogéno-tartrate de (R)-3-N,N-dicyclobutylamino-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide notamment son tartrate-(2R,3R), et plus particulièrement le monohydrate de tartrate-(2R,3R) hydrogéno (R-3-N,N-dicyclobutylamino-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide. L'invention concerne également des procédés de production de ce tartrate, l'utilisation de ce sel en médecine, l'utilisation du tartrate dans la production de formulations pharmaceutiques, et un procédé de traitement de troubles du système nerveux central par administration du tartrate chez un hôte nécessitant un tel traitement.
Nyqvist Hakan
Sohn Daniel D.
Astra Aktiebolag
Fetherstonhaugh & Co.
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