A scalable method of preserving biologically active...

C - Chemistry – Metallurgy – 12 – N

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C12N 1/04 (2006.01) A01N 1/02 (2006.01) A01N 3/00 (2006.01) A61K 9/12 (2006.01) A61K 47/26 (2006.01) A61K 47/30 (2006.01) B01J 13/00 (2006.01) C12N 9/04 (2006.01) C12N 9/96 (2006.01)

Patent

CA 2260233

A method of preserving sensitive biological dispersions, suspensions, emulsions and solutions by forming stable foams from fluid materials to be dehydrated, as an aid both to the drying of one or more biologically active substrates in the fluid and as an aid in preparing an easily divisible dried product suitable for further commercial use. The stable foams are formed by partially removing the water to form a viscous liquid and by further subjecting the reduced liquid to vacuum, to cause it to "boil" during further drying at temperatures substantially lower than 100 degrees C. In other words, reduced pressure is applied to viscous solutions or suspensions of biologically active materials to cause the solutions or suspensions to foam during boiling, and during the foaming process further solvent removal causes the ultimate production of a stable open-cell or closed-cell foam.

L'invention concerne un procédé permettant de préserver des dispersions biologiques, des suspensions, des émulsions et des solutions sensibles par la formation de mousses stables à partir de matériaux fluides destinés à être déshydratés, utile en tant qu'aide au séchage d'un ou de plusieurs substrats biologiquement actifs dans le fluide, et à la préparation d'un produit séché facilement divisible, approprié à un usage commercial postérieur. On forme les mousses stables par élimination partielle d'eau afin d'obtenir un liquide visqueux, et en soumettant ensuite ce liquide réduit à un vide pour provoquer une ébullition au cours d'un séchage ultérieur, à des températures sensiblement inférieures à 100 ·C. En d'autres termes, on applique une pression réduite à des solutions visqueuses ou des suspensions de matériaux biologiquement actifs pour provoquer la formation de mousse au cours de l'ébullition de celles-ci, et, au cours de cette formation de mousse, une élimination additionnelle de solvant provoque la production ultime d'une mousse stable à alvéoles ouverts ou fermés.

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