A screening method and compounds for treating friedreich ataxia

Details A screening method and compounds for treating friedreich ataxia A screening method and compounds for treating friedreich ataxia

G - Physics

01

N

G01N 33/68 (2006.01) A61K 31/12 (2006.01)

Patent

CA 2489294

The present invention relates to a method for identifying and/or validating candidate substances for the treatment of Friedreich Ataxia (FRDA). Furthermore, the present invention relates to the use of selenium, Ebselen and Glutathione peroxidase (GPX) mimetics for the preparation of a medicament for the treatment of FRDA. Another aspect of the present invention relates to the use of cells with reduced frataxin expression for identifying and/or validating candidate substances for the treatment of Friedreich Ataxia.

L'invention concerne une m~thode d'identification et/ou de validation de substances candidates pour le traitement de la maladie de Friedreich. Par ailleurs, l'invention porte sur l'utilisation de substances mim~tiques de la gluthation p~roxydase (GPX), du s~l~nium et de l'Ebs~l­ne pour la pr~paration d'un m~dicament pour le traitement de ladite maladie. Selon un autre aspect de l'invention, l'utilisation de cellules ~ expression r~duite de frataxine pour l'identification et/ou la validation de substances candidates pour le traitement de la maladie de Friedreich est d~crite.

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