C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/81 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2690113
The present invention relates to a cell comprising an Endoplasmic Reticulum (ER) stress element operably linked to a reporter element and an exogenous gene encoding a protein that induces ER stress. Methods of screening using the modified cell, constructs used in the modified cell, the candidate agents identified by the screen and uses thereof are also part of the invention.
L'invention concerne une cellule comprenant un élément de stress réticulum endoplasmique (ER) lié opérationnellement à un élément reporteur et un gène exogène codant pour une protéine induisant le stress ER. Elle concerne également des procédés de criblage utilisant la cellule modifiée, des constructions utilisées dans la cellule modifiée, des agents candidats identifiés par le tamis et des utilisations de ceux-ci.
Calado Patricia Ramalhete Mendes Da Silva
Cerejo Marta Isabel Heitor
Chatterjee Sukalyan
Dos Santos Alexandra Maria Barros
Moreira de Oliveira Vieira Helena Margarida
Bioalvo - Servicos Investigacao E. Desenvolvimento Em Biotecnologia S.a.
Smart & Biggar
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