C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/02 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2527858
There is provided a rapid and simple screening method of a substance with an antidepressant action. The screening method of a substance with an antidepressant action in accordance with the invention includes a cell preparation step for preparing a cell showing a predetermined electrophysiological response on a given stimulation and modifying the electrophysiological response when in contact to a depression-related substance, a candidate substance treatment step for putting a candidate substance as a screening subject and the depression-related substance in contact to the prepared cell and assaying the electrophysiological response of the cell, a control treatment step for putting the depression-related substance in contact to the prepared cell and assaying the modification of the electrophysiological response, and an assessment step for assessing whether or not the modification of the electrophysiological response as assayed at the control treatment step is suppressed in the assay results obtained at the candidate substance treatment step.
Kawato Suguru
Oishi Yuki
Smart & Biggar
The University Of Tokyo
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