A screening system for identifying drug-drug interactions...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) C40B 30/00 (2006.01) C40B 30/06 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2459055

The invention features a method of screening for drug-drug interactions using combinational arrays. The method includes the steps of: (a) providing (i) a test drug; (ii) a drug library; and (iii) an assay, (b) contacting the test drug and at least some of the library drugs from the drug library in the assay under conditions that ensure that each test drug/library drug contacting is segretated from the others, (c) recording the result of the contacting of the test drug and the library drug in the assay, and (d) identifying combinations of drugs that produce a result in the assay that is different from the results produced by either drug of the combination by itself. According to the method, each of the identified combinations indicates an interaction between the test drug and the library drug.

L'invention concerne une méthode de criblage d'interactions médicamenteuses dans laquelle sont utilisés des jeux d'échantillons combinés. Cette méthode consiste (a) à sélectionner (i) un médicament test, (ii) une banque de médicaments, et (iii) un dosage; (b) à mettre en contact le médicament test et au moins certains des médicaments de la banque dans le dosage dans des conditions garantissant que chaque mise en contact du médicament test et du médicament de la banque est isolée des autres; (c) à enregistrer le résultat de la mise en contact du médicament test et du médicament de la banque dans le dosage; et (d) à identifier des combinaisons de médicaments produisant dans le dosage un résultat différent des résultats produits par chaque médicament de la combinaison seul. Selon cette méthode, chacune des combinaisons identifiées indique une interaction entre le médicament test et le médicament de la banque.

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