A segment of glycosylation-deficient hgf alpha-chain

Details A segment of glycosylation-deficient hgf alpha-chain A segment of glycosylation-deficient hgf alpha-chain

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 31/7088 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07K 14/475 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2494384

The present invention provides a segment of glycosylation-deficient HGF having mutation(s) introduced into an amino acid sequence so as to prevent glycosylation at least one glycosylation site of a hepatocyte growth factor (HGF), and a method of producing the same. The segment of glycosylation-deficient HGF of the present invention has the same activity as that of a segment of glycosylated HGF, therefore, it is useful as an alternate for a segment of glycosylated HGF.

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