A shape-based approach for scaffoldless tissue engineering

A - Human Necessities – 61 – F

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A61F 2/02 (2006.01) A61K 35/32 (2006.01) C12N 5/00 (2006.01)

Patent

CA 2648332

Methods for forming tissue engineered constructs without the use of scaffolds and associated methods of use in tissue replacement are provided. One example of a method may comprise providing a shaped hydrogel negative mold; seeding the mold with cells; allowing the cells to self-assemble in the mold to form a tissue engineered construct.

L'invention concerne des procédés pour former des constructions de tissu artificiel sans utiliser d'échafaudages, ainsi que des procédés d'utilisation associés pour remplacer un tissu. Dans un mode de réalisation, le procédé consiste à disposer d'un moule négatif en hydrogel façonné, à ensemencer le moule de cellules et à permettre aux cellules de s'auto-assembler dans le moule pour former une construction de tissu artificiel.

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