A simplified and improved method for preparing an antibody...

Details A simplified and improved method for preparing an antibody... A simplified and improved method for preparing an antibody...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 9/127 (2006.01) A61K 31/7088 (2006.01) A61K 35/76 (2006.01) A61K 38/17 (2006.01) A61K 47/30 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2442533

A method of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprises the steps of (a) preparing an antibody or antibody fragment; (b) mixing said antibody or antibody fragment with a cationic liposome to form a cationic immunoliposome or with a cationic polymer to form a polyplex; and (c) mixing said cationic immunoliposome or said polyplex with a therapeutic or diagnostic agent to form said antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex.

L'invention concerne un procédé de préparation d'un immunoliposome cationique ou d'un complexe polymère cationique ciblé sur un anticorps ou un fragment d'anticorps, procédé consistant a) à préparer un anticorps ou un fragment d'anticorps, b) à mélanger cet anticorps ou ce fragment d'anticorps avec un liposome cationique pour former un immunoliposome cationique ou avec un polymère cationique pour former un polyplexe, et c) à mélanger cet immunoliposome cationique ou ce polyplexe avec un agent thérapeutique ou diagnostique pour former l'immunoliposome cationique ou le complexe polymère cationique ciblé sur un anticorps ou un fragment d'anticorps.

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