C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) G01N 33/50 (2006.01) G01N 33/52 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2449708
The present invention is related to the detection of GPCR ligands in a test sample by using a single cell biosensor expressing a GPCR. Preferably, the test sample is derived from a biological or environmental sample. This invention may be used to detect the presence of a disease or to detect the presence of a harmful agent in the environment. Included in the present invention is an array of biosensors that detect ligands of various GPCRs.
L'invention concerne la détection de ligands GPCR dans un échantillon à essai au moyen d'un biocapteur monocellulaire exprimant un GPCR. De préférence, l'échantillon pour essai provient d'un échantillon biologique ou d'un échantillon prélevé dans l'environnement. On peut utiliser cette invention pour dépister une maladie ou détecter la présence d'un agent dangereux dans l'environnement. Enfin, l'invention concerne un jeu de biocapteurs qui détectent les ligands de divers GPCR.
Barak Lawrence S.
Caron Marc G.
Oakley Robert H.
Shetzline Michael A.
Duke University
Marks & Clerk
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