C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2278342
Aortic-preferentially-expressed gene-1 (APEG-1) and striated muscle preferentially expressed (SPEG) polypeptide, DNA sequences encoding and controlling the transcription of the APEG-1/SPEG encoding gene, methods of diagnosing vascular injury, methods of conferring smooth muscle-cell specific expression, and methods of inhibiting vascular smooth muscle cell proliferation by increasing the level of APEG-1 at the site of vascular injury.
La présente invention concerne un gène 1 s'exprimant de préférence dans l'aorte (APEG-1) et un polypeptide s'exprimant de préférence dans les muscles striés (SPEG), des séquences d'ADN codant et commandant la transcription du gène codant APEG-1/SPEG, des procédés de diagnostic de blessures vasculaires, des procédés permettant de conférer une expression spécifique des cellules musculaires lisses, et des procédés permettant d'inhiber la prolifération des cellules musculaires lisses en augmentant le niveau d'APEG-1 sur le site de la blessure vasculaire.
Hsieh Chung-Ming
Lee Mu-En
Kirby Eades Gale Baker
President And Fellows Of Harvard College
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