A single gene encoding aortic-specific and striated-specific...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) C07K 14/47 (2006.01) C12N 15/09 (2006.01) C12N 15/85 (2006.01) C12Q 1/66 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2340428

Aortic-preferentially-expressed gane-1 (APEG-1) and striated muscle preferentially expressed (SPEG) polypeptide, DNA sequences encoding and controlling the transcription of the APEG-1'/SPEG encoding gene, methods of diagnosing vascular injury, methods of conferring smooth muscle-cell specific expression, and methods of inhibiting vascular smooth muscle cell proliferation by increasing the level of APEG-1 at the site of vascular injury.

L'invention porte sur un polypeptide du gène-1 exprimé de préférence par les muscles aortiques (APEG-1) et sur un polypeptide du gène-1 exprimé de préférence par les muscles striés (SPEG), sur des séquences d'ADN codant et régulant la transcription du gène codant APEG-1/SPEG, sur des méthodes de diagnostic des lésions vasculaires, sur des procédés visant à conférer une expression spécifique aux cellules des muscles lisses et sur des procédés visant à inhiber la prolifération des cellules des muscles lisses vasculaires par augmentation du taux d'APEG-1 sur le site de la lésion vasculaire.

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