A solid phase synthesis reaction vessel and method of using...

B - Operations – Transporting – 01 – J

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B01J 19/00 (2006.01)

Patent

CA 2230592

A solid phase synthesis reaction vessel (1) includes a vessel (1) with a first inlet (3), a second inlet (5), and an outlet (7). A first stopcock (11) is disposed within the first inlet (3) and a second stopcock (13) is disposed within the outlet (7). Solid phase material is prevented from escaping the reaction vessel (1) via the outlet (7) while allowing fluid to flow through the outlet by a frit (9). In one embodiment, the reaction vessel (1) includes an outer hollow shell (31, 34) surrounding the vessel (1) to allow cooling or heating fluid to flow therein for controlling the temperature in the interior reaction volume (15). The solid phase synthesis reaction vessel (1) provides for the independent opening and closing of each of the inlets (3) and outlet (7) to provide for various ways of draining the vessel (1), varying the conditions within the vessel (1), and/or adding additional materials into the vessel (1).

L'invention porte sur un réacteur pour synthèses en phase solide (1) dont l'enceinte (1) comporte une première entrée (3), une deuxième entrée (5) et une sortie (7). La première entrée (3) est munie d'un premier robinet (11), et la sortie (7), d'un deuxième robinet (13). Les substances en phase solide ne peuvent quitter le réacteur par la sortie (7) tandis qu'un fluide peut le faire en traversant un verre fritté (9). Dans un mode de réalisation, le réacteur (1) comporte une enveloppe extérieure creuse (31, 34) où peut circuler un fluide de réchauffage ou de refroidissement régulant la température du volume de réaction intérieur (15). Le réacteur (1) est conçu pour pouvoir ouvrir ou fermer indépendamment les entrées (3) et la sortie (7), ce qui permet différents modes de vidage, de faire varier les conditions régnant dans le réacteur (1) et/ou d'y ajouter des substances additionnelles.

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