A soluble complex comprising a retroviral surface glycoprotein

Details A soluble complex comprising a retroviral surface glycoprotein A soluble complex comprising a retroviral surface glycoprotein

C - Chemistry, Metallurgy

12

N

C12N 9/90 (2006.01) A61K 38/52 (2006.01) A61K 39/21 (2006.01) A61K 47/48 (2006.01) C07K 14/16 (2006.01) G01N 33/543 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2450476

The present invention relates to the diagnosis of HIV infections. It especially teaches the production of a soluble retroviral surface glycoprotein- (or transmembrane glycoprotein)- chaperone complex and the advantageous use of a chaperone-antigen complex especially in the detection of antibodies to HIV in immunoassays, preferably according to the double antigen bridge concept, or as an immunogen. The invention also discloses soluble complexes comprising a variant of HIV-1 gp41 or a variant of HIV-2 gp36, respectively, and a chaperone selected from the peptidyl-prolyl-isomerase class of chaperones. Variants comprising specific amino-acid substitutions in the N- helical domain of HIV-1 gp41 or of HIV-2 gp36, respectively are also described.

La présente invention concerne le diagnostic d'infections par VIH, notamment la production d'un complexe soluble de glycoprotéine de surface rétrovirale (ou glycoprotéine transmembranaire) et de chaperon moléculaire, ainsi que l'utilisation avantageuse d'un complexe d'antigène et de chaperon moléculaire, notamment dans la détection d'anticorps du VIH dans des dosages immunologiques, de préférence selon le concept de pont antigénique double, ou en tant qu'immunogène. L'invention concerne également des complexes solubles contenant un variant de HIV-1 gp41 ou respectivement un variant de HIV-2 gp36, et un chaperon moléculaire choisi dans la classe des peptidyl-prolyl-isomérases. L'invention concerne par ailleurs des variants présentant des substitutions d'acides aminés spécifiques dans le domaine de l'hélice N de HIV-1 gp41 ou respectivement de HIV-2 gp36.

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