A soluble tumor necrosis factor receptor mutant

Details A soluble tumor necrosis factor receptor mutant A soluble tumor necrosis factor receptor mutant

C - Chemistry, Metallurgy

07

K

C07K 14/715 (2006.01) A61K 38/19 (2006.01) A61P 19/02 (2006.01) A61P 37/02 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2710040

A soluble tumor necrosis factor receptor 2 (TNFRII) mutant has an amino acid substitution at position 92Glu compared with the wild TNFRII. The mutant improves the cytotoxicity capacity of neutralizing TNFalpha and lymphotoxin. The mutant and fusion protein comprising it are useful for the treatment of TNFalpha and lymphotoxin related diseases.

Un récepteur 2 de facteur de nécrose tumorale (TNFR2) mutant et soluble présente une substitution d'acide aminé à la position 92 Glu par rapport au TNFRII de type sauvage. La mutation augmente l'effet cytotoxique des TNF-alpha et TNF-beta. La mutation et la protéine de fusion en découlant peuvent être utilisées dans le traitement des maladies liées aux TNF-alpha et TNF-beta.

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