A stabilised phenylalanine ammmonia lyase

Details A stabilised phenylalanine ammmonia lyase A stabilised phenylalanine ammmonia lyase

C - Chemistry, Metallurgy

12

N

C12N 15/60 (2006.01) A61K 38/51 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 9/88 (2006.01) C12N 9/96 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2165281

This invention relates to stabilisation of phenylalanine ammonia lyase against proteolytic degradation by chemical modification, e.g. with crosslinking agents, or by genetic modification, a phenylalanine ammonia lyase variant, a method of preparing the variant and a pharmaceutical composition containing phenylalanine ammonia lyase.

L'invention se rapporte à la stabilisation de la phénylalanine ammoniac lyase contre la dégradation protéolytique par modification chimique, par exemple avec des agents de réticulation ou par modification génétique; elle concerne également un variant de la phénylalanine ammoniac lyase, une méthode de préparation de ce variant et une composition pharmaceutique contenant la phénylalanine ammoniac lyase.

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