A stabilized azithromycin composition

C - Chemistry – Metallurgy – 07 – H

Patent

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C07H 17/00 (2006.01) A61K 31/7052 (2006.01)

Patent

CA 2544755

A method for preparing a stabilized azithromycin composition comprising mixing azithromycin monohydrate and water to form a stabilized azithromycin composition having a water content from about 5 to about 15 weight percent, based on the total weight of the composition, wherein said method is conducted within a humidity range of 20-99% relative humidity. The present inventors have unexpectedly determined that a certain amount of water is necessary to stabilize a pharmaceutical composition comprising azithromycin monohydrate. In addition, the stabilized azithromycin monohydrate compositions do not require an antioxidant.

L'invention concerne un procédé de préparation d'une composition d'azithromycine stabilisée consistant à mélanger du monohydrate d'azithromycine et de l'eau de manière à former une composition d'azithromycine stabilisée comprenant une teneur en eau comprise entre environ 5 et environ 15 % en poids, en fonction du poids total de la composition, le procédé étant mis en oeuvre dans une gamme d'humidité comprise entre 20-99 % d'humidité relative. Il a été déterminé de manière inattendue qu'une certaine quantité d'eau est nécessaire pour stabiliser une composition pharmaceutique comprenant du monohydrate d'azithromycine. De plus, un antioxydant n'est pas nécessaire dans les compositions de monohydrate d'azithromycine stabilisées.

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