A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/27 (2006.01) A61K 9/19 (2006.01) A61K 47/02 (2006.01) A61K 47/18 (2006.01) A61K 47/26 (2006.01)
Patent
CA 2226523
A pharmaceutical formulation comprising a growth hormone pre-treated with zinc and optionally lysine or calcium ions shows a very high stability against deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows for the storing and shipment thereof in a lyophilized state or in the form of a dissolved or re-dissolved formulation at ambient temperature.
Une formulation pharmaceutique comprenant une hormone de croissance pré-traitée avec des ions zinc et facultativement lysine ou calcium présente une très haute stabilité contre la déamidation, l'oxidation et le clivage de liaisons peptidiques. La stabilité du produit permet son stockage et son expédition à l'état lyophilisé ou sous la forme d'une formulation dissoute ou redissoute à température ambiante.
Balschmidt Per
Christensen Thorkild
Olsen Ole Hvilsted
Sorensen Hans Holmegaard
Thim Lars
Mccarthy Tetrault Llp
Novo Nordisk A/s
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