A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/27 (2006.01) A61K 47/42 (2006.01)
Patent
CA 2226553
A pharmaceutical formulation comprising a growth hormone and a peptide comprising at least one basic amino acid residue and at least one acid amino acid residue as additive or buffering substance shows a very high stability against deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows for the storing and shipment thereof in a lyophilized state or in the form of a dissolved or re-dissolved formulation at ambient temperature.
Formulation pharmaceutique comportant une hormone de croissance et un peptide contenant au moins un reste d'acide aminé basique et au moins un reste d'acide aminé acide en tant qu'additif ou substance de tamponnage, qui possède une stabilité très élevée contre la déamidation, l'oxydation et le clivage des liaison peptidiques. La stabilité du produit en permet le stockage et le transport sous forme lyophilisée ou sous forme d'une formulation dissoute ou redissoute à température ambiante.
Balschmidt Per
Christensen Thorkild
Olsen Ole Hvilsted
Sorensen Hans Holmegaard
Thim Lars
Mccarthy Tetrault Llp
Novo Nordisk A/s
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