A stabilized polymeric delivery system

Details A stabilized polymeric delivery system A stabilized polymeric delivery system

A - Human Necessities

61

K

A61K 9/50 (2006.01) A61K 9/52 (2006.01) A61K 9/62 (2006.01) A61K 9/64 (2006.01)

Patent

CA 2586846

The invention relates to a delivery system for the sustained and controlled delivery of a group of bioactive agents. More particularly, the invention relates to a delivery system and a method for delivery of a bioactive agent containing a nucleophilic functional group by means of a biodegradable, sustained-release implant. The implant may be a preformed implant, microparticles or an in situ formed implant. The implant includes a biodegradable thermoplastic polymer, the bioactive agent having a nucleophilic group substituent and a stabilizing associate as well as other optional components. The combination of the stabilizing associate with the bioactive agent prevents and/or minimizes and/or lessens degradation of the thermoplastic polymer by the bioactive agent.

L'invention concerne un système d'administration pour une distribution soutenue et régulée d'un groupe d'agents bioactifs. En particulier, l'invention concerne un système d'administration et un procédé pour distribuer un agent bioactif contenant un groupe fonctionnel nucléophile au moyen d'un implant à libération soutenue, biodégradable. L'implant peut être un implant préformé, des microparticules ou un implant formé in situ. L'implant comprend un polymère thermoplastique biodégradable, un agent bioactif présentant un substituant du groupe nucléophile et un agent associé de stabilisation ainsi que d'autres composants. L'association de l'agent associé de stabilisation et de l'agent bioactif empêche et/ou minimise et/ou diminue la dégradation du polymère thermoplastique par l'agent bioactif.

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